Saturday, 30 March 2013

synthesis of norfloxacin


DescriptionA synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]

Categories
  • Anti-Infectives
  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Quinolones
  • Nucleic Acid Synthesis Inhibitors

PharmacodynamicsNorfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Mechanism of actionThe bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity


synthesis of norfloxacin:

Following is one of the synthesis routes: 1-Ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) is condensed with piperazine (II) to produce Norfloxacin in the condition of heating at 170 C in water in a pressure tube.
Production of Norfloxacin

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Thursday, 14 March 2013

spam infection In my facebook

sorry nayeb . it not a work by me .it just spam infection. 
sorry

please come back.
i really sorry..........
please NAYU.........




Sunday, 10 March 2013

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