http://www.ziddu.com/download/20049467/GGUFINALYEARCHEMISTRYPAPERIISLB.pdf.html
M.Sc. part
–ll Compulsory Papers
BIOINOGRANIC
, BIOORGANIC, BIOPHYSICAL AND ENVIRONMENTAL CHEMISTRY
PAPER -II
A . BIOINORGANIC CHEMISTRY:
35hrs
i).Metal ions in biological systems:
2 hrs
Essential and trace metals
ii).Na+/k+ pump
3 hrs
Role of metal ions in biological
processes
iii).Bioenergetics and ATP cycle:
8 hrs
DNA polymerization , glucose storage ,
metal complexes in transmission of energy chlorophylls. Photosystem l and
photosystem ll in cleavage of water Model systems
iv).Transport and storage of dioxygen:
10 hrs
Heme protein and oxygen uptake .
structure and function of hemoglobin myoglobin Hemocyanins . hemerythren .model
synthetic complexe of iron .co and Cu
v).Electron transfer in biology:
6 hrs
Structure and function of
metallo-proteins in electron transfer
processes Cytochromes and ion-sulphur proteins , synthetic models.
vi).Nitrogenase:
6 hrs
Biological nitrogen fixation
Mo-Nitrogenase spectroscopic and other evidences . other nitrogenase and model
systems
B .BIOORGANIC CHEMISTRY
35 hrs
i.)Introduction:
Basic considerations, proximity effects and
molecular adaption
ii.)Enzymes:
8 hrs
Introduction and historical perspective ,
Chemical and biological catalysis remarkable property of enzymes, like
catalytic powder . specificity and regulation Nomenclature and Classification
.Extraction and purification,fischer’s Lock and key and koshland’s Induced Fit
hypothesis.concept and identification of active site by the use of inhibitors
affinity labeling and enzyme modification by site directed mutiagenesis
kinetics Reversible and irreversible inhibition
iii.)Mechanism of Enzyme Action:
3 hrs
Transition State theory, orientation
and steric effect. Acid – base catalysis covalent catalysis strain or
distortion. Example of some typically enzyme mechanism for chymotryps in
ribonuclease .lysozyme and carboxypeptidase A
iv.)kind of Reaction catalysed by Enzymes:
8 hrs
Nuceophilic displacement on a
phosphorus atom. Multiple displacement reaction and coupling of ATP cleavage to
endergonic processes . transfer of sulphate , addition elimination
reactions,enolic intermediates in isomerisation reactions.B-cleavage and
condensation , some isomerisation and
rearrangement reactions. Enzyme catalysed carboxylation and decarboxylation
V.)Co-enzyme Chemistry: 4
hrs
Cofactors as derived from vitamin
coenzyme prosteric groups apoenzymes structure and biological functions of
coenzyme A ,thiamin pyrophosphate . pyridoxal phosphate NAD NADP FAD.Lipoic acid vitamin B ,
Mechanism of reactions catalysed by cofactors
vi.)Enzyme Models:
4
hrs
Host gust chemistry .
chiral recognition and catalysis Molecular recognition Molecular asymmetry and
prochirality . Biomimc….. chemistry , crown ether cryptates cyclodextrin.
Cyclodextrin-based enzyme models, calixarenes . ionophores , micelles synthetic
enzymes or synzymes.
vii.)Biotechnological Application of Enzymes:
5 hrs
Large scale
production and purification of enzymes. Techniques and methods of
immobilization of enzymes , effect of immobilization on enzyme activity
application of immobilized enzymes use of enzymes in food and drink
industry-brewing and cheese-making . sy………….. from corn starch . enzymes as
targets for drug design . clinical uses of enzymes. Enzyme therapy . Enzymes
and recombinant DNA technologi
C. BIOPHYSICAL CHEMISTRY:
37 hrs
① Biological
cell and its constituents:
5 hrs
Biological cell, structure and function of proteins , enzyme .DNA and
RNA in living systems. Helix coil transation .
② Bioenergetics
: 4
hrs
Stander free energy change in biochemical reactions
exergonic , endergonic hydrolysis of ATP . synthesis of ATP from ADP
③ Statistical Mechanics in Biopolymers:
6 hrs Chain configuration of
macromolecules , statistical distribution end to end dimensions , calculation
of average dimension for various chain structure , polypeptide and protein
structure. Introduction to protein folding problem
④ Biopolymer
Interactions:
6 hrs
Force involving in biopolymer interactions. Electrostatic changes and
molecular expansion , hydrophobic forces , dispersion force interactions.
Multiple equilibria and various types of binding processes in biological system
, H+ ion titration .
⑤ Thermodynamic of biopolymer solutions:
5 hrs
Thermodynamic of biopolymer
solutions , osmotic pressure , membrane equilibrium. Muscular contraction and
energy generation In mechano-chemical systems
⑥ Cell
membrance and transport of ions:
3 hrs
Structure and function of
cellmembrane ion transport through cell membranes, irreversi……..thermodynamic
treatment of membrance transport Nerve conduction
⑦
Biopolymers and their Molecular weights:
6 hrs
Evaluation of size shape molecular weight and exten ……………..dration of
biopolymers by various experimental techniques . sedime………on equilibrum
hydrodynamic methods . diffusion sedimentration …………………………..viscocity ,
electrophoresis and totational motions
⑧
Diffraction Methods: 4
hrs
Light scattering , low angle X-ray scattering, x-ray
diffraction and photocorrelation spectroscopy
D.
ENVIRONMENTAL CHEMISTRY:
30 hrs
①
Environment:
8 hrs
Introduction , composition of atmosphere , vertical temperature …………
……………………………………………………………………………………………………………….Biochemical cycles of C , N , P, S
and O Biodistribution of elements.
②Hydrosphere:
12 hrs
Chemical composition of water bodies-lakes , streams…..ers and wetlands
etc. hydrological cycle ,aquatic pollution : inorganic organic pesticide ,
agriculture , industrial , and sewage , detergents. ………………………..and oil
pollutions.
Water quality parameters – dissolved oxygen ,BOD , solid , metals ,
sulphate , phosphate , nitrate , microorganism . water quality standard ,
analytical method of measuring BOD , DO , COD , F . Oils metals (As , Cd , Hg ,
Pb) Residual chloride and chloride demands , Purification and treatment of
water.
③Industrial
Pollution:
10 hrs
Cement , suger , distillery .
paper and pulp , thermal power plants , Nuclear power plants . Radio Nucleide
analysis , disposal of ………… and their management .
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